ZIA CP010144-10475 (ZIA) | |||
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Title | Studies of Immune Functions in Patients with Fanconi Anemia | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Giri | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $48,647 | Project Dates | 04/22/2009 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Chemoprevention (20.0%) Childhood Cancers (100.0%) |
Breast (2.0%) Buccal Cavity (25.0%) Cervical Cancer (5.0%) Childhood Leukemia (100.0%) Esophagus (8.0%) Head and Neck (25.0%) Leukemia (35.0%) Liver Cancer (5.0%) Pancreas (5.0%) Vaginal (5.0%) |
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Research Type | |||
Normal Functioning Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
To characterize immune system function in patients with Fanconi Anemia by studying mononuclear cells and serum/plasma to determine: 1) lymphoproliferative responses to common recall antigens; 2) cytokine profile in plasma and serum; 3) role of regulatory T-cells. Cryopreserved mononuclear cells from patients and family members with other inherited bone marrow failure syndromes will be used as controls. This work has now begun, with the support of a research grant from the Fanconi Anemia Research Foundation. |